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Cortisone In A Patch

Cortisone In A Patch

Cornell University researchers demonstrate the electrospinning of hydrocortisone/cyclodextrin complex nanofibers was performed in order to develop a fast-dissolving oral drug delivery system. Hydrocortisone is a water-insoluble hydrophobic drug, yet, the water solubility of hydrocortisone was significantly enhanced by inclusion complexation with hydroxypropyl-beta-cyclodextrin. The results suggest that polymer-free electrospun nanofibrous webs produced from hydrocortisone/HP-β-CyD could be quite applicable for fast-dissolving oral drug delivery systems.

Asli Celebioglu and Tamer Uyar, “Hydrocortisone/cyclodextrin complex electrospun nanofibers for a fast-dissolving oral drug delivery system,” RSC Med. Chem., 2020, Advance Article. https://doi.org/10.1039/C9MD00390H

Fast Dissolving Fibers

Fast Dissolving Fibers

Cornell University researchers demonstrate electrospinning of nanofibers from alpha-lipoic acid/cyclodextrin inclusion complex systems was successfully performed without having any polymeric matrix. Alpha-lipoic acid (α-LA) is a natural antioxidant compound which is widely used as a food supplement. However, it has limited water solubility and poor thermal and oxidative stability. Nevertheless, it is possible to enhance its water solubility and thermal stability by inclusion complexation with cyclodextrins.

Asli Celebioglu and Tamer Uyar, “Encapsulation and Stabilization of α-Lipoic Acid in Cyclodextrin Inclusion Complex Electrospun Nanofibers: Antioxidant and Fast-Dissolving α-Lipoic Acid/Cyclodextrin Nanofibrous Webs,” Journal of Agricultural and Food Chemistry 2019 67 (47), 13093-13107, https://doi.org/10.1021/acs.jafc.9b05580

Asli Celebioglu and Tamer Uyar, “Encapsulation and Stabilization of α-Lipoic Acid in Cyclodextrin Inclusion Complex Electrospun Nanofibers: Antioxidant and Fast-Dissolving α-Lipoic Acid/Cyclodextrin Nanofibrous Webs,” Journal of Agricultural and Food Chemistry 2019 67 (47), 13093-13107, https://doi.org/10.1021/acs.jafc.9b05580

Anti-Oxidant Food Supplement

Anti-Oxidant Food Supplement

Cornell University researchers produce complex nanofibrous webs using electrospinning technique for the purpose of orally fast-dissolving antioxidant food supplement. Curcumin was totally preserved without any loss during the electrospinning process. The aqueous solutions of curcumin/HP-β-CyD and curcumin/HP-γ-CyD were yielded uniform fiber morphology with ~200 nm and ~900 nm average fiber diameter, respectively. Curcumin is a natural bioactive compound with poor water-solubility, however, the phase solubility test and dissolution/disintegration tests (water and artificial saliva) revealed that the water-solubility of curcumin was prominently improved.

 

Asli Celebioglu, Tamer Uyar, “Fast-dissolving antioxidant curcumin/cyclodextrin inclusion complex electrospun nanofibrous webs,” Food Chemistry, Volume 317, 2020, 126397, ISSN 0308-8146, https://doi.org/10.1016/j.foodchem.2020.126397