Cortisone In A Patch
Cornell University researchers demonstrate the electrospinning of hydrocortisone/cyclodextrin complex nanofibers was performed in order to develop a fast-dissolving oral drug delivery system. Hydrocortisone is a water-insoluble hydrophobic drug, yet, the water solubility of hydrocortisone was significantly enhanced by inclusion complexation with hydroxypropyl-beta-cyclodextrin. The results suggest that polymer-free electrospun nanofibrous webs produced from hydrocortisone/HP-β-CyD could be quite applicable for fast-dissolving oral drug delivery systems.
Asli Celebioglu and Tamer Uyar, “Hydrocortisone/cyclodextrin complex electrospun nanofibers for a fast-dissolving oral drug delivery system,” RSC Med. Chem., 2020, Advance Article. https://doi.org/10.1039/C9MD00390H